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Buy TB-500 10mg Australia
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Description
TB-500 is a synthetic peptide fragment corresponding to the active actin-binding domain of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino acid protein present in virtually all human and animal cells. The active fragment functions as an actin-sequestering agent, binding G-actin monomers to regulate cytoskeletal remodelling and facilitate controlled cell migration during the repair process, a mechanism central to wound healing, angiogenesis, and tissue regeneration research. TB-500 promotes endothelial cell migration and new vessel formation, and research has documented anti-inflammatory effects via downregulation of inflammatory cytokines in cardiac and skeletal muscle injury models. A notable series of preclinical studies demonstrated improved cardiac function parameters following TB-500 administration in rodent myocardial infarction models, one of the few peptides with documented cardiac progenitor cell recruitment activity in published literature. TB-500 is frequently combined with BPC-157 in musculoskeletal research protocols, with complementary mechanisms (BPC-157 via VEGFR2/FAK signalling; TB-500 via actin regulation and endothelial migration) producing broader tissue coverage than either compound alone. Sequence: Ac-SDKPDMAEIEKFDKSKLKKTETEQEKNTLPT. CAS: 77591-33-4. Format: lyophilised powder, 10mg per vial. Reconstitute with bacteriostatic water; store at 2-8°C post-reconstitution and use within 28 days. For research use only. Not for human consumption.
What Is TB-500?
TB-500 is a synthetic peptide fragment of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino acid protein involved in actin polymerisation, cell migration, and wound healing. The active fragment corresponds to the actin-binding domain of the full protein. Thymosin Beta-4 is one of the most abundant peptides in mammalian tissue and plays a central role in cytoskeletal organisation.
TB-500 research focuses primarily on its capacity to promote healing in muscle, tendon, and cardiac tissue, contexts where actin dynamics and cell mobility are critical to the repair process.
Mechanism of Action
TB-500's primary mechanism involves sequestering G-actin (globular actin) monomers, which prevents premature actin polymerisation and facilitates controlled cytoskeletal remodelling during the repair process. This actin-regulatory activity promotes cell migration, a prerequisite for effective wound healing.
Additionally, TB-500 stimulates endothelial cell migration and promotes angiogenesis, improving vascularisation of injured tissue. Research has also documented anti-inflammatory effects, with downregulation of inflammatory cytokines in cardiac and skeletal muscle injury models.
In cardiac research, TB-500 has demonstrated the ability to stimulate cardiomyocyte migration and promote cardiac progenitor cell recruitment in preclinical infarction models, one of the few peptides with documented cardiac repair signalling in the published literature.
Research Evidence
Musculoskeletal healing research has shown consistent accelerated recovery in tendon, ligament, and muscle injury models treated with TB-500 versus vehicle controls. A notable series of studies by Goldstein and colleagues documented improved cardiac function parameters in rodent myocardial infarction models following TB-500 administration.
TB-500 is frequently combined with BPC-157 in research protocols, the combination leverages complementary mechanisms: BPC-157's VEGF/FAK signalling with TB-500's actin-regulatory and cardiac repair pathways, providing broader tissue coverage than either compound alone. OzPeps stocks both individually and as a pre-blended combination.
Supplied for laboratory research use only. No human clinical trials have been conducted.
Reconstitution & Storage
TB-500 10mg is supplied as lyophilised powder. Reconstitute with bacteriostatic water, 2ml per 10mg vial gives 5mg/ml. Store lyophilised at −20°C; reconstituted at 2–8°C for up to 4 weeks. Do not shake or vortex.
Research Guide Available , read the science, mechanism, and research data for this compound.
Frequently Asked Questions
Research Use Only: This product is for laboratory research purposes only. Not for human consumption. All compounds are sourced from suppliers with a verified Certificate of Analysis (COA).
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